Yeast cells are helpful to display screen for mutations that control γ-secretase activity. during the present study, we identified Aph1 mutants that have protease exercise in the absence of NCT. We identified that these mutants Increased γ-secretase endoproteolysis exercise with full subunits. We propose which the underlying mutations trigger conformational variations in PS1 to reinforce protease activity.
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Pelajar SMP tawarkan layanan seks, 'terindikasi korban eksploitasi seksual' dan 'titik kritis' pendidikan seks anak
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